Publications

Selected Publications

Tomazou, Marios, et al. “Computational re-design of synthetic genetic oscillators for independent amplitude and frequency modulation.” Cell systems 6.4 (2018): 508-520.

Nicolaidou,I., Tozzi, F., Kindynis, P., Panagiotou, M., & Antoniades, A. (under review). Development and usability of a serious game for mobile devices (app) to scaffold children in managing stress: an evaluation study. Italian Journal of Educational Technology, Special issue on Digital games learning.

Tozzi, F., Nicolaidou, I. Kindynis, Ph. Panagiotou, M., Vogazianos, P. Nicolaou, E., Kamilari, E., Christodoulou, A. & Antoniades, A. (accepted). How do parents select educational apps for young children? International Conference of the Learning Sciences 2018 (to be presented in June 2018)

A. L. Rivas, G. Leitner, M. D. Jankowski, A. L. Hoogesteijn, M. J. Iandiorio, S. Chatzipanagiotou, A. Ioannidis, S. E. Blum, R. Piccinini, and A. Antoniades, “Nature and Consequences of Biological Reductionism for the immunological Study of infectious Diseases,” Frontiers in Immunology, vol. 8, p. 612, 2017.

A. Antoniades, A. Aristodimou, C. Georgousopoulos, N. Forgó, A. Gledson, P. Hasapis, C. Vandeleur, K. Perakis, R. Sahay, and M. Mehdi, “Advancing clinical research by semantically interconnecting aggregated medical data information in a secure context,” Health and Technology, vol. 7, no. 2–3, pp. 223–240, 2017.

I. Nicolaidou, F. Tozzi, P. Kindynis, M. Panagiotou, and A. Antoniades, “An Interactive Storytelling Game for Mobile Devices for Children’s Stress Management,” in European Conference on Games Based Learning, 2017, pp. 967–971.

E. Dardiotis, E. Panayiotou, A. Provatas, K. Christodoulou, A. Hadjisavvas, A. Antoniades, A. Lourbopoulos, M. Pantzaris, N. Grigoriadis, and G. M. Hadjigeorgiou, “Gene variants of adhesion molecules act as modifiers of disease severity in MS,” Neurology-Neuroimmunology Neuroinflammation, vol. 4, no. 4, p. e350, 2017.

C. Votsi, C. Toufexis, K. Michailidou, A. Antoniades, N. Skordis, M. Karaolis, C. S. Pattichis, and K. Christodoulou, “Type 2 Diabetes Susceptibility in the Greek-Cypriot Population: Replication of Associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 Polymorphisms,” Genes, vol. 8, no. 1, p. 16, 2017.

A. Antoniades, C. S. Pattichis, C. N. Schizas, and P. D. Bamidis, Introductory editorial to the special issue on systems medicine for the delivery of better healthcare services. Springer Berlin Heidelberg, 2016.

A. Aristodimou, A. Antoniades, and C. S. Pattichis, “Privacy preserving data publishing of categorical data through k-anonymity and feature selection,” Healthcare technology letters, vol. 3, no. 1, pp. 16–21, 2016.

A. Antoniades, I. Nicolaidou, D. Spachos, J. Mylläri, D. Giordano, E. Dafli, E. Mitsopoulou, C. N. Schizas, C. Pattichis, M. Nikolaidou, and P. Bamidis, “Medical Content Searching, Retrieving, and Sharing Over the Internet: Lessons Learned From the mEducator Through a Scenario-Based Evaluation,” ResearchGate, vol. 17, no. 10, p. e229, Oct. 2015.

I. Nicolaidou, A. Antoniades, R. Constantinou, C. Marangos, E. Kyriacou, P. Bamidis, E. Dafli, and C. S. Pattichis, “A Virtual Emergency Telemedicine Serious Game in Medical Training: A Quantitative, Professional Feedback-Informed Evaluation Study,” J. Med. Internet Res., vol. 17, no. 6, p. e150, 2015.

I. Nicolaidou, A. Antoniades, R. Constantinou, C. Marangos, E. Kyriacou, P. Bamidis, and C. Pattichis, “The Potential of Educational Games in Telemedicine: What do Usability Evaluation Results Say?,” in Global Learn, 2015, vol. 2015, pp. 492–501.

M. S. Neofytou, K. Neokleous, A. Aristodemou, I. Constantinou, Z. Antoniou, E. C. Schiza, C. S. Pattichis, and C. N. Schizas, “Electronic Health Record Application Support Service Enablers,” in 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015, pp. 1401–1404.

E. Abdelhamid, R. Alhajj, A. Antoniades, M. T. Arredondo, C. Balas, P. Bamidis, N. G. Bourbakis, A. Bucur, P. Chan, Y. Chen, and others, “BIBE 2014 Program Committee.”
V. Boraska et al., “A genome-wide association study of anorexia nervosa,” Mol Psychiatry, vol. 19, no. 10, pp. 1085–1094, Oct. 2014.

“A genomewide association study of smoking relapse in four Eu… : Psychiatric Genetics,” LWW. [Online]. Available: http://journals.lww.com/psychgenetics/Fulltext/2013/08000/A_genomewide_association_study_of_smoking_relapse.1.aspx. [Accessed: 13-Jan-2017].

D. Tian, A. Gledson, A. Antoniades, A. Aristodimou, N. Dimitrios, R. Sahay, J. Pan, S. Stivaros, G. Nenadic, X. Zeng, and others, “A Bayesian Association Rule Mining Algorithm,” in 2013 IEEE International Conference on Systems, Man, and Cybernetics, 2013, pp. 3258–3264.

O. D. Beyan, A. Iqbal, Y. Khan, A. Antoniades, J. Keane, P. Hasapis, C. Georgousopoulos, M. Ioannidi, S. Decker, and R. Sahay, “Querying phenotype-genotype associations across multiple knowledge bases using Semantic Web technologies,” in Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on, 2013, pp. 1–5.

P. Hasapis, D. Ntalaperas, C. C. Kannas, A. Aristodimou, D. Alexandrou, T. Bouras, C. Georgousopoulos, A. Antoniades, C. S. Pattichis, and A. Constantinou, “Molecular clustering via knowledge mining from biomedical scientific corpora,” in Bioinformatics and Bioengineering (BIBE), 2013 IEEE 13th International Conference on, 2013, pp. 1–5.

S. Abdelwahed, R. Abdullah, D. G. Abel, M. A. R. Ahad, M. Aiello, L. H. Alencar, M. H. Alencar, B. Alidaee, E. Alonso, S. Alonso, and others, “SMC 2013.”

A. Antoniades, T. Marangos, E. Kyriacou, I. Nicolaidou, E. Dafli, P. Bamidis, and C. Pattichis, “VIRTUAL TELEMEDICINE: A SERIOUS GAME TO DEVELOP PROBLEM SOLVING SKILLS IN MEDICAL EDUCATION,” EDULEARN12 Proceedings, pp. 3612–3619, 2012.

A. Antoniades, C. Georgousopoulos, N. Forgo, A. Aristodimou, F. Tozzi, P. Hasapis, K. Perakis, T. Bouras, D. Alexandrou, E. Kamateri, and others, “Linked2Safety: A secure linked data medical information space for semantically-interconnecting EHRs advancing patients’ safety in medical research,” in Bioinformatics & Bioengineering (BIBE), 2012 IEEE 12th International Conference on, 2012, pp. 517–522.

A. Antoniades, J. Keane, A. Aristodimou, C. Philipou, A. Constantinou, C. Georgousopoulos, F. Tozzi, K. Kyriacou, A. Hadjisavvas, M. Loizidou, and others, “The effects of applying cell-suppression and perturbation to aggregated genetic data,” in Bioinformatics & Bioengineering (BIBE), 2012 IEEE 12th International Conference on, 2012, pp. 644–649.
A. Aristodimou, A. Antoniades, and C. Pattichis, “Clustering subjects in genetic studies with Self Organizing Maps,” in Bioinformatics & Bioengineering (BIBE), 2012 IEEE 12th International Conference on, 2012, pp. 546–551.

I. Nicolaidou, A. Antoniades, C. Marangos, E. Dafli, E. Kyriacou, P. Bamidis, and C. Pattichis, “THE INSTRUCTIONAL DESIGN OF VIRTUAL TELEMEDICINE: A SIMULATION-BASED SERIOUS GAME IN HEALTH-CARE,” ICERI2012 Proceedings, pp. 5746–5755, 2012.

I. Nicolaidou, A. Antoniades, J. Mylläri, D. Giordano, E. Dafli, C. Schizas, P. Constantinos, M. Nikolaidou, D. Spachos, and P. Bamidis, “Scenario-Based Evaluation for User Testing of Medical Educational Content-Sharing Solutions,” INTED2012 Proceedings, pp. 2619–2626, 2012.

M. Rivera, S. Cohen-Woods, K. Kapur, G. Breen, M. Y. Ng, A. W. Butler, N. Craddock, M. Gill, A. Korszun, W. Maier, O. Mors, M. J. Owen, M. Preisig, S. Bergmann, F. Tozzi, J. Rice, M. Rietschel, J. Rucker, A. Schosser, K. J. Aitchison, R. Uher, I. W. Craig, C. M. Lewis, A. E. Farmer, and P. McGuffin, “Depressive disorder moderates the effect of the FTO gene on body mass index,” Mol Psychiatry, vol. 17, no. 6, pp. 604–611, Jun. 2012.

A. Antoniades, “Discovering disease associated gene-gene interactions: A two SNP interaction analysis framework,” May 2011.

A. Antoniades, I. Nicolaidou, J. Mylläri, D. Giordano, E. Dafli, C. Pattichis, M. Nikolaidou, and P. Bamidis, “DESIGN OF EVALUATION OF CONTENT SHARING SOLUTIONS IN MEDICAL EDUCATION,” ICERI2011 Proceedings, pp. 6786–6794, 2011.

F. Tozzi, M. Manchia, N. W. Galwey, G. Severino, M. Del Zompo, R. Day, K. Matthews, J. Strauss, J. L. Kennedy, P. McGuffin, J. B. Vincent, A. Farmer, and P. Muglia, “Admixture analysis of age at onset in bipolar disorder,” Psychiatry Research, vol. 185, no. 1–2, pp. 27–32, Jan. 2011.

I. Nicolaidou, D. Giordano, C. Spampinato, C. Pattichis, P. Bamidis, A. Antoniades, T. Bastiaens, and M. Ebner, “Evaluation of educational content sharing solutions: Challenges of the mEducator best practice network,” in Proceedings of the World Conference on Educational Multimedia, Hypermedia and Telecommunications. Chesapeake, VA: Association for the Advancement of Computing in Education, 2011, pp. 498–503.

I. Nicolaidou, P. Bamidis, A. Antoniades, M. Nikolaidou, C. Pattichis, and D. Giordano, “mEducator: Multi type content sharing and repurposing in medical education,” in EdMedia: World Conference on Educational Media and Technology, 2011, vol. 2011, pp. 3740–3745.

P. Belmonte Mahon, M. Pirooznia, F. S. Goes, F. Seifuddin, J. Steele, P. H. Lee, J. Huang, M. L. Hamshere, T. W. T. C. C. C. B. D. G. The Bipolar Genome Study (BiGS) Consortium, J. R. DePaulo, J. R. Kelsoe, M. Rietschel, M. Nöthen, S. Cichon, H. Gurling, S. Purcell, J. W. Smoller, N. Craddock, T. G. Schulze, F. J. McMahon, J. B. Potash, and P. P. Zandi, “Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder,” Am. J. Med. Genet., vol. 156, no. 3, pp. 370–378, Apr. 2011.

A. Antoniades, P. M. Matthews, C. S. Pattichis, and N. W. Galwey, “A computationally fast measure of epistasis for 2 SNPs and a categorical phenotype,” in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010, pp. 6194–6197.

E. Domenici, D. R. Willé, F. Tozzi, I. Prokopenko, S. Miller, A. McKeown, C. Brittain, D. Rujescu, I. Giegling, C. W. Turck, F. Holsboer, E. T. Bullmore, L. Middleton, E. Merlo-Pich, R. C. Alexander, and P. Muglia, “Plasma Protein Biomarkers for Depression and Schizophrenia by Multi Analyte Profiling of Case-Control Collections,” PLOS ONE, vol. 5, no. 2, p. e9166, Feb. 2010.

F. C. Calboli, F. Tozzi, N. W. Galwey, A. Antoniades, V. Mooser, M. Preisig, P. Vollenweider, D. Waterworth, G. Waeber, M. R. Johnson, and others, “A genome-wide association study of neuroticism in a population-based sample,” PloS one, vol. 5, no. 7, p. e11504, 2010.

F. C. F. Calboli, F. Tozzi, N. W. Galwey, A. Antoniades, V. Mooser, M. Preisig, P. Vollenweider, D. Waterworth, G. Waeber, M. R. Johnson, P. Muglia, and D. J. Balding, “A Genome-Wide Association Study of Neuroticism in a Population-Based Sample,” PLOS ONE, vol. 5, no. 7, p. e11504, Jul. 2010.

P. Muglia, F. Tozzi, N. W. Galwey, C. Francks, R. Upmanyu, X. Q. Kong, A. Antoniades, E.Domenici, J. Perry, S. Rothen, C. L. Vandeleur, V. Mooser, G. Waeber, P. Vollenweider, M. Preisig, S. Lucae, B. Müller-Myhsok, F. Holsboer, L. T. Middleton, and A. D. Roses, “Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts,” Mol Psychiatry, vol. 15, no. 6, pp. 589–601, Jun. 2010.

P. Muglia, F. Tozzi, N. W. Galwey, C. Francks, R. Upmanyu, X. Q. Kong, A. Antoniades, E. Domenici, J. Perry, S. Rothen, C. L. Vandeleur, V. Mooser, G. Waeber, P. Vollenweider, M. Preisig, S. Lucae, B. Müller-Myhsok, F. Holsboer, L. T. Middleton, and A. D. Roses, “Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts,” Mol Psychiatry, vol. 15, no. 6, pp. 589–601, Jun. 2010.

S. Scherag, J. Hebebrand, and A. Hinney, “Eating disorders: the current status of molecular genetic research,” Eur Child Adolesc Psychiatry, vol. 19, no. 3, pp. 211–226, Mar. 2010.
A. Antoniades, I. Kalvari, C. Pattichis, N. Jones, P. M. Matthews, E. Domenici, and P. Muglia, “Discovering genetic polymorphism associated with gene expression levels across the whole genome,” in 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009, pp. 5466–5469.

L. J. Scott, P. Muglia, X. Q. Kong, W. Guan, M. Flickinger, R. Upmanyu, F. Tozzi, J. Z. Li, M. Burmeister, D. Absher, R. C. Thompson, C. Francks, F. Meng, A. Antoniades, A. M. Southwick, A. F. Schatzberg, W. E. Bunney, J. D. Barchas, E. G. Jones, R. Day, K. Matthews, P. McGuffin, J. S. Strauss, J. L. Kennedy, L. Middleton, A. D. Roses, S. J. Watson, J. B. Vincent, R. M. Myers, A. E. Farmer, H. Akil, D. K. Burns, and M. Boehnke, “Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry,” PNAS, vol. 106, no. 18, pp. 7501–7506, May 2009.

L. J. Scott, P. Muglia, X. Q. Kong, W. Guan, M. Flickinger, R. Upmanyu, F. Tozzi, J. Z. Li, M. Burmeister, D. Absher, and others, “Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry,” Proceedings of the National Academy of Sciences, vol. 106, no. 18, pp. 7501–7506, 2009.

M. Preisig, G. Waeber, P. Vollenweider, P. Bovet, S. Rothen, C. Vandeleur, P. Guex, L. Middleton, D. Waterworth, V. Mooser, F. Tozzi, and P. Muglia, “The PsyCoLaus study: methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factors,” BMC Psychiatry, vol. 9, p. 9, 2009.

A. Antoniades, L. Loizou, A. Aristodimou, and C. S. Pattichis, “A binary format for genetic data designed for large whole genome studies that enable both marker and strand based analyses,” in BioInformatics and BioEngineering, 2008. BIBE 2008. 8th IEEE International Conference on, 2008, pp. 1–4.

F. Tozzi, I. Prokopenko, J. D. Perry, J. L. Kennedy, A. D. McCarthy, F. Holsboer, W. Berrettini, L. T. Middleton, H. D. Chilcoat, and P. Muglia, “Family history of depression is associated with younger age of onset in patients with recurrent depression,” Psychological Medicine, vol. 38, no. 5, pp. 641–649, May 2008.

W. Berrettini, X. Yuan, F. Tozzi, K. Song, C. Francks, H. Chilcoat, D. Waterworth, P. Muglia, and V. Mooser, “α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking,” Mol Psychiatry, vol. 13, no. 4, pp. 368–373, Jan. 2008.

“Features Associated With Laxative Abuse in Individuals With… : Psychosomatic Medicine,” LWW. [Online]. Available: http://journals.lww.com/psychosomaticmedicine/Fulltext/2006/05000/Features_Associated_With_Laxative_Abuse_in.18.aspx. [Accessed: 13-Jan-2017].

F. Tozzi, L. M. Thornton, K. L. Klump, M. M. Fichter, K. A. Halmi, A. S. Kaplan, M. Strober, D. B. Woodside, S. Crow, J. Mitchell, A. Rotondo, M. Mauri, G. Cassano, P. Keel, K. H. Plotnicov, C. Pollice, L. R. Lilenfeld, W. H. Berrettini, C. M. Bulik, and W. H. Kaye, “Symptom Fluctuation in Eating Disorders: Correlates of Diagnostic Crossover,” AJP, vol. 162, no. 4, pp. 732–740, Apr. 2005.

G. K. Giannikis, A. Antoniades, and D. Politis, “An Intelligent Web-based System for Social Scenarios in Archaeology,” WSEAS Transactions on Computers, vol. 4, no. 9, pp. 1193–1201, 2005.

G. K. Giannikis, A. Antoniades, and D. Politis, “ArchES: a rule-based system for hypothetical social scenarios in archaeology,” expert systems, vol. 1, p. 2, 2005.
B. A. Julstrom and A. Antoniades, “Three evolutionary codings of rectilinear Steiner arborescences,” in Genetic and Evolutionary Computation Conference, 2004, pp. 1282–1291.
B. A. Julstrom and A. Antoniades, “Two hybrid evolutionary algorithms for the rectilinear Steiner arborescence problem,” in Proceedings of the 2004 ACM symposium on Applied computing, 2004, pp. 980–984.

C. Pattichis, E. Kyriakou, A. Pitsillides, G. Samaras, C. N. Schizas, M. Neophytou, A. Antoniades, A. Kouppis, V. Tanos, and A. Jossif, “Experience with Healthcare Telematics in Cyprus,” in Proceedings of the European Federation for Medical Informatics Special Topic Conference, 2004, vol. 13, p. 16.

F. Tozzi, S. H. Aggen, B. M. Neale, C. B. Anderson, S. E. Mazzeo, M. C. Neale, and C. M. Bulik, “The Structure of Perfectionism: A Twin Study,” Behav Genet, vol. 34, no. 5, pp. 483–494, Sep. 2004.

C. M. Bulik, F. Tozzi, C. Anderson, S. E. Mazzeo, S. Aggen, and P. F. Sullivan, “The Relation Between Eating Disorders and Components of Perfectionism,” AJP, vol. 160, no. 2, pp. 366–368, Feb. 2003.

F. Tozzi, P. F. Sullivan, J. L. Fear, J. McKenzie, and C. M. Bulik, “Causes and recovery in anorexia nervosa: The patient’s perspective,” Int. J. Eat. Disord., vol. 33, no. 2, pp. 143–154, Mar. 2003.

T. F, B. Aw, and B. Cm, “Candidate gene studies in eating disorders.,” Psychopharmacol Bull, vol. 36, no. 3, pp. 60–90, 2002.