STATUS
Past project
STARTING/ENDING
2019 – 2023
FUNDING
Public; Cyprus Research and Innovation Foundation
STREMBLE’S ROLE
Bioinformatics leader
STREMBLE’S ROLE
Stremble performs all the 16S metagenomics bioinformatics analysis and statistical analysis of combined omics data modalities.
- Bioinformatics
- Data analytics
- multi-omics approaches
ABOUT MOLECULAR COLONOSCOPY (MOCO) PROJECT
The MOCO project falls within the broader Cyprus Intestinal Health Study (CyIHS) which aims to understand and characterize Gut Microbiota of the Cypriot population as a means for preventing the development of colorectal neoplasias.
The clinical study has collected blood, tissue and faecal samples from over 320 individuals along with medical history, lifestyle and dietary information. Individuals at high-risk of colorectal cancer were identified based on the number of adenomas or polyps counted in the colon during routine colonoscopy. Multi-omics analytics were carried out using metagenomic sequencing analysis of bacterial DNA and Gas Chromatography Mass Spectrometry (GC/MS) analysis of faecal metabolites. This information will assist in the development of faecal biomarkers of colorectal cancer which could replace the more invasive and costly colonoscopy screening procedures.
The project results have been published in high-impact scientific journals.
VISIT PROJECT WEBSITEHEALTHY CYPRIOT GUT MICROBIOMECANCER PRONE GROUP
Project website
Project website
CONSORTIUM
