STATUS
Ongoing project
STARTING/ENDING
2021 – 2025
FUNDING
Private
STREMBLE’S ROLE
Analytics and bioinformatics leader
STREMBLE’S ROLE
All of the projects 16S metagenomics DNA sequencing and bioinformatics analysis is carried out by Stremble, as well as the collection and analysis of all data from patients’ wearable devices.
- Microbiome analysis
- 16S metagenomics
- Bioinformatics
- Wearables data collection
- Data analytics
ABOUT PREBIOM PROJECT
Recently, several preclinical studies have shown the influence of the gut microbiome on the antitumor efficacy of both chemotherapy and immunotherapy agents, suggesting that bacteria-mediated interactions with the immune system are essential for optimal drug efficacy. Furthermore, patients receiving immunotherapy for advanced metastatic cancer, can be stratified into responders and on responders to immunotherapy on the basis of the composition of their intestinal microbiomes.
The aim of this study – in collaboration with an Cyprus oncology hospital – is to build a reliable model that can predict the group of lung cancer patients that are likely to respond best to Immune Checkpoint Inhibitors (ICI), and who should proceed with immunotherapy, whilst also predicting the group of patients that are unlikely to respond well to immunotherapy. This will allow an optimisation of the treatment regimes being applied and indicate where alternative avenues of treatment should be explored.
VISIT PROJECT WEBSITE
High throughput DNA sequencing is used to identify all bacteria in a patients gut microbiome.
CONSORTIUM
